The artificial organs, which include ventricular assist devices and blood pumps, require precise control of fluid dynamics to ensure biomedical applications it needs optimization to ensure biocompatibility and minimize risks associated with hemolysis, and improve drug transport efficiency. The purpose of this research is to develop a micropolar nanofluid model, which accounts for different aspects of blood flow, including microrotation of blood particles, transport mechanisms, and MHD control. The governing nonlinear partial differential equations are transformed into a dimensionless system using similarity transformations. Then, the equations are numerically solved using the method of solving a boundary value problem. It is established that the inclusion of nanoparticles increases the velocity distribution by about 15–20% while the wall shear stress distribution is reduced by about 10–18%, improving hemocompatibility. Temperature distribution decreases by about 8–12%, showing enhanced heat transfer, whereas the concentration distribution becomes significantly smaller by 30–40%, which demonstrates better drug transport efficiency. Moreover, as the value of the Hartmann number increases, there is suppression of fluctuations in the velocity field resulting from Lorentz force effects. The new model improves upon the existing models by providing better estimates of momentum, heat, and mass transfer processes. These results provide useful information regarding optimal design of artificial organs and improving hemolysis and targeted drug delivery.